Epigenetic regulation of IPF fibroblast phenotype by glutaminolysis

Epigenetic regulation of IPF fibroblast phenotype by glutaminolysis

Objective: Excessive extra-cellular-matrix production and uncontrolled proliferation of the fibroblasts are characteristics of many fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). The fibroblasts have enhanced glutaminolysis with up-regulated glutaminase, GLS1, which converts gluta...

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Bibliographic Details
Main Authors: Zheyi Xiang, Le Bai, Jennifer Q. Zhou, Ricardo R. Cevallos, Jonathan R. Sanders, Gang Liu, Karen Bernard, Yan Y. Sanders
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Molecular Metabolism
Subjects:
Glutamine
α-KG
H3K27me3
Col3A1
PLK1
Lung fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822002241

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http://www.sciencedirect.com/science/article/pii/S2212877822002241

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