Multifactorial determinants of NK cell repertoire organization: insights into age, sex, KIR genotype, HLA typing, and CMV influence

Multifactorial determinants of NK cell repertoire organization: insights into age, sex, KIR genotype, HLA typing, and CMV influence

IntroductionPolymorphisms in the KIR and HLA genes contribute to the diversity of the NK cell repertoire. Extrinsic factors also play a role in modifying this repertoire. The best example is cytomegalovirus, which promotes the expansion of memory-like NK cells. However, the mechanisms governing this...

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Bibliographic Details
Main Authors: Enora Ferron, Gaëlle David, Catherine Willem, Nolwenn Legrand, Perla Salameh, Laetitia Anquetil, Alexandre Walencik, Ketevan Gendzekhadze, Katia Gagne, Christelle Retière
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
KIR
HLA
NK cells
repertoire
CMV
CD57
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1389358/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1389358/full

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