Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation

Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation

Pathogenesis of insulin resistance in leptin-deficient ob/ob mice is obscure. In another form of diet-dependent obesity, high-fat-fed mice, hepatic insulin resistance involves ceramide-induced activation of atypical protein kinase C (aPKC), which selectively impairs protein kinase B (Akt)-dependent...

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Bibliographic Details
Main Authors: Mini P. Sajan, Robert A. Ivey, Mackenzie C. Lee, Robert V. Farese
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Journal of Lipid Research
Subjects:
atypical protein kinase C
protein kinase C-ι
protein kinase C-ζ
protein kinase B
lipogenesis
gluconeogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520356418

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http://www.sciencedirect.com/science/article/pii/S0022227520356418

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