Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation

Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation

Pathogenesis of insulin resistance in leptin-deficient ob/ob mice is obscure. In another form of diet-dependent obesity, high-fat-fed mice, hepatic insulin resistance involves ceramide-induced activation of atypical protein kinase C (aPKC), which selectively impairs protein kinase B (Akt)-dependent...

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Bibliografiske detaljer
Main Authors:	Mini P. Sajan, Robert A. Ivey, Mackenzie C. Lee, Robert V. Farese
Format:	Article
Sprog:	English
Udgivet:	Elsevier 2015-01-01
Serier:	Journal of Lipid Research
Fag:	atypical protein kinase C protein kinase C-ι protein kinase C-ζ protein kinase B lipogenesis gluconeogenesis
Online adgang:	http://www.sciencedirect.com/science/article/pii/S0022227520356418

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