Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation
Pathogenesis of insulin resistance in leptin-deficient ob/ob mice is obscure. In another form of diet-dependent obesity, high-fat-fed mice, hepatic insulin resistance involves ceramide-induced activation of atypical protein kinase C (aPKC), which selectively impairs protein kinase B (Akt)-dependent...
| Main Authors: | , , , |
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| 格式: | Article |
| 語言: | English |
| 出版: |
Elsevier
2015-01-01
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| 叢編: | Journal of Lipid Research |
| 主題: | |
| 在線閱讀: | http://www.sciencedirect.com/science/article/pii/S0022227520356418 |