Discrimination and quantification of methotrexate in the presence of its metabolites in patient serum using SERS mapping, assisted by multivariate spectral data analysis

Discrimination and quantification of methotrexate in the presence of its metabolites in patient serum using SERS mapping, assisted by multivariate spectral data analysis

Therapeutic drug monitoring (TDM) of methotrexate (MTX), an anticancer drug, is critical since MTX therapy can lead to severe adverse effects if not monitored to ensure clearance. Discriminating and quantifying MTX among its metabolites is challenging, time consuming, and not universally available....

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Bibliographic Details
Main Authors: Gohar Soufi, Elodie Dumont, Yaman Göksel, Roman Slipets, Raheel Altaf Raja, Kjeld Schmiegelow, Habib Bagheri, Anja Boisen, Kinga Zor
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biosensors and Bioelectronics: X
Online Access:http://www.sciencedirect.com/science/article/pii/S2590137023000791

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http://www.sciencedirect.com/science/article/pii/S2590137023000791

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