Flap endonuclease 1 and DNA-PKcs synergistically participate in stabilizing replication fork to encounter replication stress in glioma cells
Abstract Background Selectively utilizing alternative mechanisms to repair damaged DNA in essential factors deficient cancer facilitates tumor genetic evolution and contributes to treatment resistance. Synthetic lethality strategies provide a novel scenario to anticancer therapy with DNA repair prot...
| Auteurs principaux: | , , , , , , , , |
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| Format: | Article |
| Langue: | English |
| Publié: |
BMC
2022-04-01
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| Collection: | Journal of Experimental & Clinical Cancer Research |
| Sujets: | |
| Accès en ligne: | https://doi.org/10.1186/s13046-022-02334-0 |