Targeting hypoxia-inducible factors for breast cancer therapy: A narrative review

Targeting hypoxia-inducible factors for breast cancer therapy: A narrative review

Hypoxia-inducible factors (HIFs), central regulators for cells to adapt to low cellular oxygen levels, are often overexpressed and activated in breast cancer. HIFs modulate the primary transcriptional response of downstream pathways and target genes in response to hypoxia, including glycolysis, angi...

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Bibliographic Details
Main Authors: Shuang Luo, Yu Jiang, Anfu Zheng, Yueshui Zhao, Xu Wu, Mingxing Li, Fukuan Du, Yu Chen, Shuai Deng, Meijuan Chen, Wanping Li, Xiaobing Li, Li Gu, Yuhong Sun, Zhangang Xiao, Jing Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Pharmacology
Subjects:
hypoxia-inducible factors
breast cancer
drug delivery systems
tumor microenvironment
angiogenesis
glycolysis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1064661/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1064661/full

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