A pharmacogenetic interaction analysis of bevacizumab with paclitaxel in advanced breast cancer patients

Abstract To investigate pharmacogenetic interactions among VEGF-A, VEGFR-2, IL-8, HIF-1α, EPAS-1, and TSP-1 SNPs and their role on progression-free survival (PFS) in metastatic breast cancer (MBC) patients treated with bevacizumab plus first-line paclitaxel or with paclitaxel alone. Analyses were pe...

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Main Authors: Luigi Coltelli, Giacomo Allegrini, Paola Orlandi, Chiara Finale, Andrea Fontana, Luna Chiara Masini, Marco Scalese, Giada Arrighi, Maria Teresa Barletta, Ermelinda De Maio, Marta Banchi, Elisabetta Fini, Patrizia Guidi, Giada Frenzilli, Sara Donati, Simona Giovannelli, Lucia Tanganelli, Barbara Salvadori, Lorenzo Livi, Icro Meattini, Ilaria Pazzagli, Marco Di Lieto, Mirco Pistelli, Virginia Casadei, Antonella Ferro, Samanta Cupini, Francesca Orlandi, Damiana Francesca, Giulia Lorenzini, Leonardo Barellini, Alfredo Falcone, Alessandro Cosimi, Guido Bocci
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-022-00400-6