Tristetraprolin‐driven regulatory circuit controls quality and timing of mRNA decay in inflammation

Tristetraprolin‐driven regulatory circuit controls quality and timing of mRNA decay in inflammation

Abstract For a successful yet controlled immune response, cells need to specifically destabilize inflammatory mRNAs but prevent premature removal of those still used. The regulatory circuits controlling quality and timing in the global inflammatory mRNA decay are not understood. Here, we show that t...

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Bibliographic Details
Main Authors: Franz Kratochvill, Christian Machacek, Claus Vogl, Florian Ebner, Vitaly Sedlyarov, Andreas R Gruber, Harald Hartweger, Raimund Vielnascher, Marina Karaghiosoff, Thomas Rülicke, Mathias Müller, Ivo Hofacker, Roland Lang, Pavel Kovarik
Format: Article
Language:English
Published: Springer Nature 2011-12-01
Series:Molecular Systems Biology
Subjects:
immune homeostasis
inflammation
mRNA stability
p38 MAPK
tristetraprolin
Online Access:https://doi.org/10.1038/msb.2011.93

Internet

https://doi.org/10.1038/msb.2011.93

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