GSK-3 mouse models to study neuronal apoptosis

GSK-3 mouse models to study neuronal apoptosis

Increased GSK-3 activity is believed to contribute to the etiology of chronic disorders like Alzheimer’s disease, schizophrenia, diabetes and some types of cancer, thus supporting therapeutic potential of GSK-3 inhibitors. Numerous mouse models with modified GSK-3 have been generated in order to stu...

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Bibliographic Details
Main Authors: Raquel eGomez-Sintes, Felix eHernandez, Jose J Lucas, Jesus eAvila
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Apoptosis
Alzheimer's disease
neurodegenerative disorder
mouse models
GSK-3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2011.00045/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2011.00045/full

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