GluN2B-containing NMDA receptor attenuated neuronal apoptosis in the mouse model of HIBD through inhibiting endoplasmic reticulum stress-activated PERK/eIF2α signaling pathway

GluN2B-containing NMDA receptor attenuated neuronal apoptosis in the mouse model of HIBD through inhibiting endoplasmic reticulum stress-activated PERK/eIF2α signaling pathway

IntroductionNeonatal hypoxic-ischemic brain damage (HIBD) refers to brain damage in newborns caused by hypoxia and reduced or even stopped cerebral blood flow during the perinatal period. Currently, there are no targeted treatments for neonatal ischemic hypoxic brain damage, primarily due to the inc...

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Bibliographic Details
Main Authors: Mengxue Wu, Shilian Xu, Kai Mi, Shuang Yang, Yuanyuan Xu, Jie Li, Junyang Chen, Xiaomin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
hypoxic–ischemic brain damage
GluN2B
ER stress
UPR
PERK
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1375843/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2024.1375843/full

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