Oral TNF-α siRNA delivery via milk-derived exosomes for effective treatment of inflammatory bowel disease

Oral TNF-α siRNA delivery via milk-derived exosomes for effective treatment of inflammatory bowel disease

Oral administration facilitates the direct delivery of drugs to lesions within the small intestine and colon, making it an ideal approach for treating patients with inflammatory bowel disease. However, multiple physical barriers impede the delivery of oral RNA drugs through the gastrointestinal trac...

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Bibliographic Details
Main Authors: Geonhee Han, Hyosuk Kim, Hochung Jang, Eun Sun Kim, Sun Hwa Kim, Yoosoo Yang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-04-01
Series:Bioactive Materials
Subjects:
Milk-derived exosome
Oral gene delivery
siRNA
Inflammatory bowel disease
TNF-α
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X23004061

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http://www.sciencedirect.com/science/article/pii/S2452199X23004061

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