Dendritic Cells Actively Limit Interleukin-10 Production Under Inflammatory Conditions via DC-SCRIPT and Dual-Specificity Phosphatase 4

Dendritic Cells Actively Limit Interleukin-10 Production Under Inflammatory Conditions via DC-SCRIPT and Dual-Specificity Phosphatase 4

Dendritic cell (DC)-based immunotherapy makes use of the DC’s ability to direct the adaptive immune response toward activation or inhibition. DCs perform this immune orchestration in part by secretion of selected cytokines. The most potent anti-inflammatory cytokine interleukin-10 (IL-10) is under t...

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Bibliographic Details
Main Authors: Jonas Nørskov Søndergaard, Simon J. van Heeringen, Maaike W. G. Looman, Chunling Tang, Vassilis Triantis, Pauline Louche, Eva M. Janssen-Megens, Anieta M. Sieuwerts, John W. M. Martens, Colin Logie, Hendrik G. Stunnenberg, Marleen Ansems, Gosse J. Adema
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
ZNF366
ERK
chromatin immunoprecipitation sequencing
dual-specificity phosphatase 4
dendritic cells
MAPK
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01420/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01420/full

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