Inhibition of EGF and CoCl2-Induced HIF-1α and VEGF Production in Triple Negative MDA-MB-468 Cells by Umbelliprenin: Unveiling the Role of PI3K/AKT/mTOR and MAPK Pathways

Inhibition of EGF and CoCl2-Induced HIF-1α and VEGF Production in Triple Negative MDA-MB-468 Cells by Umbelliprenin: Unveiling the Role of PI3K/AKT/mTOR and MAPK Pathways

Background and objectives: Triple-negative breast cancer is a significant global health challenge, and there's growing interest in targeting multiple pathways for treatment. Umbelliprenin, derived from herbal sources, has shown anti-tumor potential. This study aimed to assess umbelliprenin'...

Full description

Bibliographic Details
Main Authors: Roya Atabakhshian, Melina Moshirpour, Mohammad Hadi Farjoo, Shiva Ghafghazi, Seyed Ali Ziai*
Format: Article
Language:English
Published: Iranian Society of Pharmacognosy 2024-01-01
Series:Research Journal of Pharmacognosy
Subjects:
angiogenesis inhibitors
breast neoplasm
medicinal plants
metastasis
umbelliprenin
Online Access:https://www.rjpharmacognosy.ir/article_182092_1a75bc1ba5e5d03ce02d30edf23b35f4.pdf

Internet

https://www.rjpharmacognosy.ir/article_182092_1a75bc1ba5e5d03ce02d30edf23b35f4.pdf

Similar Items