Total Body Irradiation Forever? Optimising Chemotherapeutic Options for Irradiation-Free Conditioning for Paediatric Acute Lymphoblastic Leukaemia

Total Body Irradiation Forever? Optimising Chemotherapeutic Options for Irradiation-Free Conditioning for Paediatric Acute Lymphoblastic Leukaemia

Total-body irradiation (TBI) based conditioning prior to allogeneic hematopoietic stem cell transplantation (HSCT) is generally regarded as the gold-standard for children >4 years of age with acute lymphoblastic leukaemia (ALL). Retrospective studies in the 1990's suggested better surviv...

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Bibliographic Details
Main Authors: Khalil Ben Hassine, Madeleine Powys, Peter Svec, Miroslava Pozdechova, Birgitta Versluys, Marc Ansari, Peter J. Shaw
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Pediatrics
Subjects:
acute lymphoblastic leukaemia (ALL)
hematopoietic stem cell transplant (HSCT)
chemotherapy
pharmacokinetics
pharmacogenetics
pharmacodynamics (PD)
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2021.775485/full

Internet

https://www.frontiersin.org/articles/10.3389/fped.2021.775485/full

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