Genetic inactivation of the Carnitine/Acetyl-Carnitine mitochondrial carrier of Yarrowia lipolytica leads to enhanced odd-chain fatty acid production

Genetic inactivation of the Carnitine/Acetyl-Carnitine mitochondrial carrier of Yarrowia lipolytica leads to enhanced odd-chain fatty acid production

Abstract Background Mitochondrial carriers (MCs) can deeply affect the intracellular flux distribution of metabolic pathways. The manipulation of their expression level, to redirect the flux toward the production of a molecule of interest, is an attractive target for the metabolic engineering of euk...

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Bibliographic Details
Main Authors: Eugenia Messina, Camilla Pires de Souza, Claudia Cappella, Simona Nicole Barile, Pasquale Scarcia, Isabella Pisano, Luigi Palmieri, Jean-Marc Nicaud, Gennaro Agrimi
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Microbial Cell Factories
Subjects:
Yarrowia lipolytica
Mitochondrial carrier
Carnitine/Acetyl-Carnitine shuttle
Acetyl-CoA
Metabolic engineering
Odd-chain fatty acids (OCFAs)
Online Access:https://doi.org/10.1186/s12934-023-02137-8

Internet

https://doi.org/10.1186/s12934-023-02137-8

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