Molecular Taxonomy of Systemic Lupus Erythematosus Through Data-Driven Patient Stratification: Molecular Endotypes and Cluster-Tailored Drugs

Molecular Taxonomy of Systemic Lupus Erythematosus Through Data-Driven Patient Stratification: Molecular Endotypes and Cluster-Tailored Drugs

ObjectivesTreatment of Systemic Lupus Erythematosus (SLE) is characterized by a largely empirical approach and relative paucity of novel compound development. We sought to stratify SLE patients based on their molecular phenotype and identify putative therapeutic compounds for each molecular fingerpr...

Full description

Bibliographic Details
Main Authors: Panagiotis Garantziotis, Dimitrios Nikolakis, Stavros Doumas, Eleni Frangou, George Sentis, Anastasia Filia, Antonis Fanouriakis, George Bertsias, Dimitrios T. Boumpas
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
molecular taxonomy
drug response prediction
systemic lupus erythematosus
drug repurposing
endotypes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.860726/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.860726/full

Similar Items