Gene expression profile of human T cells following a single stimulation of peripheral blood mononuclear cells with anti-CD3 antibodies

Gene expression profile of human T cells following a single stimulation of peripheral blood mononuclear cells with anti-CD3 antibodies

Abstract Background Anti-CD3 immunotherapy was initially approved for clinical use for renal transplantation rejection prevention. Subsequently, new generations of anti-CD3 antibodies have entered clinical trials for a broader spectrum of therapeutic applications, including cancer and autoimmune dis...

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Bibliographic Details
Main Authors: Isabel Garcia Sousa, Kelly Cristina Rodrigues Simi, Manuela Maragno do Almo, Maryani Andressa Gomes Bezerra, Gero Doose, Tainá Raiol, Peter F. Stadler, Steve Hoffmann, Andréa Queiroz Maranhão, Marcelo Macedo Brigido
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Genomics
Subjects:
Anti-CD3
RNA-seq
Antibody therapy
Regulatory T cells
Antibody engineering
Online Access:http://link.springer.com/article/10.1186/s12864-019-5967-8

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http://link.springer.com/article/10.1186/s12864-019-5967-8

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