TGFβ and Hippo Signaling Pathways Coordinate to Promote Acinar to Ductal Metaplasia in Human Pancreas

TGFβ and Hippo Signaling Pathways Coordinate to Promote Acinar to Ductal Metaplasia in Human Pancreas

Background & Aims: Acinar-to-ductal metaplasia (ADM) serves as a precursor event in the development of pancreatic ductal adenocarcinoma (PDAC) upon constitutive environmental and genetical stress. While the role of ADM in PDAC progression has been established, the molecular mechanisms underlying...

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Bibliographic Details
Main Authors: Michael Nipper, Yi Xu, Jun Liu, Xue Yin, Zhijie Liu, Zhengqing Ye, Jianmin Zhang, Yidong Chen, Pei Wang
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
acinar-to-ductal metaplasia
ATAC-seq
ChIP-Seq
Hippo pathway
TGFβ signaling
Online Access:https://www.mdpi.com/2073-4409/13/2/186

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https://www.mdpi.com/2073-4409/13/2/186

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