Regulation of TSC2 lysosome translocation and mitochondrial turnover by TSC2 acetylation status

Regulation of TSC2 lysosome translocation and mitochondrial turnover by TSC2 acetylation status

Abstract Sirtuin1 (SIRT1) activity decreases the tuberous sclerosis complex 2 (TSC2) lysine acetylation status, inhibiting the mechanistic target of rapamycin complex 1 (mTORC1) signalling and concomitantly, activating autophagy. This study analyzes the role of TSC2 acetylation levels in its translo...

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Bibliographic Details
Main Authors: Patricia Marqués, Jesús Burillo, Carlos González-Blanco, Beatriz Jiménez, Gema García, Ana García-Aguilar, Sarai Iglesias-Fortes, Ángela Lockwood, Carlos Guillén
Format: Article
Language:English
Published: Nature Portfolio 2024-05-01
Series:Scientific Reports
Subjects:
TSC2
Acetylation
Lysosome
mTORC1
Mitophagy
Pancreatic β cells
Online Access:https://doi.org/10.1038/s41598-024-63525-7

Internet

https://doi.org/10.1038/s41598-024-63525-7

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