The experimental model of type 2 diabetes mellitus caused by a high-fat diet with low-dose streptozotocin in rats

Aim. To develop a pathogenetically reasonable model of type 2 diabetes with marked peripheral insulin resistance and relative insulin deficiency in rats using a high-fat diet and a single injection of streptozotocin in the low dose.Materials and methods. Experiments were conducted on 16 outbred male...

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Bibliographic Details
Main Authors: O. A. Kaydash, V. V. Ivanov, A. I. Vengerovsky, E. E. Buyko, I. A. Schepetkin
Format: Article
Language:English
Published: Siberian State Medical University (Tomsk) 2020-07-01
Series:Бюллетень сибирской медицины
Subjects:
Online Access:https://bulletin.ssmu.ru/jour/article/view/2858