A Model of Glucocorticoid Receptor Interaction With Coregulators Predicts Transcriptional Regulation of Target Genes

A Model of Glucocorticoid Receptor Interaction With Coregulators Predicts Transcriptional Regulation of Target Genes

Regulatory factors that control gene transcription in multicellular organisms are assembled in multicomponent complexes by combinatorial interactions. In this context, nuclear receptors provide well-characterized and physiologically relevant systems to study ligand-induced transcription resulting fr...

Full description

Bibliographic Details
Main Authors: Federico Monczor, Antonia Chatzopoulou, Carlos Daniel Zappia, René Houtman, Onno C. Meijer, Carlos P. Fitzsimons
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Pharmacology
Subjects:
transcriptional activity
cofactor interaction
nuclear receptor
receptor allosterism
glucocorticoid receptor
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00214/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00214/full

Similar Items