Ultra-sensitive molecular detection of gene fusions from RNA using ASPYRE

Ultra-sensitive molecular detection of gene fusions from RNA using ASPYRE

Abstract Background RNA is a critical analyte for unambiguous detection of actionable mutations used to guide treatment decisions in oncology. Currently available methods for gene fusion detection include molecular or antibody-based assays, which suffer from either being limited to single-gene targe...

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Bibliographic Details
Main Authors: Eleanor R Gray, Justyna M Mordaka, Efthimia R Christoforou, Kristine von Bargen, Nicola D Potts, Christina Xyrafaki, Ana-Luisa Silva, Magdalena Stolarek-Januszkiewicz, Katarzyna Anton, Paulina K Powalowska, Simonetta Andreazza, Alessandro Tomassini, Rebecca N Palmer, Aishling Cooke, Robert J Osborne, Barnaby W Balmforth
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Medical Genomics
Subjects:
RNA
Gene fusions
NSCLC
Sensitive
Molecular detection
Online Access:https://doi.org/10.1186/s12920-022-01363-0

Internet

https://doi.org/10.1186/s12920-022-01363-0

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