Mitochondrial impairment induced by chenodeoxycholic acid: The protective effect of taurine and carnosine supplementation
<p>The cholestatic liver disease ensues with a hepatic accumulation of cytotoxic molecules. Several hydrophobic bile acids are known as cytotoxic agents accumulated in the liver during cholestasis. Chenodeoxycholic acid (CDCA) is a toxic hydrophobic bile acid. Oxidative stress and mitochondria...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2018-05-01
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| Series: | Trends in Pharmaceutical Sciences |
| Online Access: | http://tips.sums.ac.ir/index.php/TiPS/article/view/182 |
| _version_ | 1811266973736108032 |
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| author | Reza Heidari Narges Abdoli Mohammad Mehdi Ommati Akram Jamshidzadeh Hossein Niknahad |
| author_facet | Reza Heidari Narges Abdoli Mohammad Mehdi Ommati Akram Jamshidzadeh Hossein Niknahad |
| author_sort | Reza Heidari |
| collection | DOAJ |
| description | <p>The cholestatic liver disease ensues with a hepatic accumulation of cytotoxic molecules. Several hydrophobic bile acids are known as cytotoxic agents accumulated in the liver during cholestasis. Chenodeoxycholic acid (CDCA) is a toxic hydrophobic bile acid. Oxidative stress and mitochondrial dysfunction are well-known mechanisms of bile acids cytotoxicity. In the current study, CDCA effect on isolated liver mitochondria was monitored by analyzing the changes in mitochondrial dehydrogenases activity, mitochondrial permeabilization, and mitochondrial membrane potential. On the other hand, taurine (1 mM) and carnosine (1 mM) were added as potential protective agents against CDCA-induced mitochondrial dysfunction. Increasing concentrations of CDCA (100 µM - 1000 µM) impaired mitochondrial membrane potential, decreased mitochondrial dehydrogenases activity and enhanced mitochondrial permeabilization and swelling. It was found that taurine and carnosine supplementation preserved mitochondrial function in the presence of CDCA. The results mention that toxicologically relevant concentrations of CDCA impaired mitochondrial function. On the other hand, taurine and carnosine might be applicable as protective agents against bile acids-induced mitochondrial impairment and toxicity.</p> |
| first_indexed | 2024-04-12T20:54:04Z |
| format | Article |
| id | doaj.art-ddcf6a8313b849ddbca581de9ee99589 |
| institution | Directory Open Access Journal |
| issn | 2423-3722 2423-5652 |
| language | English |
| last_indexed | 2024-04-12T20:54:04Z |
| publishDate | 2018-05-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Trends in Pharmaceutical Sciences |
| spelling | doaj.art-ddcf6a8313b849ddbca581de9ee995892022-12-22T03:17:03ZengShiraz University of Medical SciencesTrends in Pharmaceutical Sciences2423-37222423-56522018-05-014210.1111/tips.v4i2.182120Mitochondrial impairment induced by chenodeoxycholic acid: The protective effect of taurine and carnosine supplementationReza Heidari0Narges AbdoliMohammad Mehdi OmmatiAkram JamshidzadehHossein NiknahadShiraz University of Medical Sciences, Pharmaceutical Sciences Research Center<p>The cholestatic liver disease ensues with a hepatic accumulation of cytotoxic molecules. Several hydrophobic bile acids are known as cytotoxic agents accumulated in the liver during cholestasis. Chenodeoxycholic acid (CDCA) is a toxic hydrophobic bile acid. Oxidative stress and mitochondrial dysfunction are well-known mechanisms of bile acids cytotoxicity. In the current study, CDCA effect on isolated liver mitochondria was monitored by analyzing the changes in mitochondrial dehydrogenases activity, mitochondrial permeabilization, and mitochondrial membrane potential. On the other hand, taurine (1 mM) and carnosine (1 mM) were added as potential protective agents against CDCA-induced mitochondrial dysfunction. Increasing concentrations of CDCA (100 µM - 1000 µM) impaired mitochondrial membrane potential, decreased mitochondrial dehydrogenases activity and enhanced mitochondrial permeabilization and swelling. It was found that taurine and carnosine supplementation preserved mitochondrial function in the presence of CDCA. The results mention that toxicologically relevant concentrations of CDCA impaired mitochondrial function. On the other hand, taurine and carnosine might be applicable as protective agents against bile acids-induced mitochondrial impairment and toxicity.</p>http://tips.sums.ac.ir/index.php/TiPS/article/view/182 |
| spellingShingle | Reza Heidari Narges Abdoli Mohammad Mehdi Ommati Akram Jamshidzadeh Hossein Niknahad Mitochondrial impairment induced by chenodeoxycholic acid: The protective effect of taurine and carnosine supplementation Trends in Pharmaceutical Sciences |
| title | Mitochondrial impairment induced by chenodeoxycholic acid: The protective effect of taurine and carnosine supplementation |
| title_full | Mitochondrial impairment induced by chenodeoxycholic acid: The protective effect of taurine and carnosine supplementation |
| title_fullStr | Mitochondrial impairment induced by chenodeoxycholic acid: The protective effect of taurine and carnosine supplementation |
| title_full_unstemmed | Mitochondrial impairment induced by chenodeoxycholic acid: The protective effect of taurine and carnosine supplementation |
| title_short | Mitochondrial impairment induced by chenodeoxycholic acid: The protective effect of taurine and carnosine supplementation |
| title_sort | mitochondrial impairment induced by chenodeoxycholic acid the protective effect of taurine and carnosine supplementation |
| url | http://tips.sums.ac.ir/index.php/TiPS/article/view/182 |
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