The Antidepressant Mirtazapine Inhibits Hepatic Innate Immune Networks to Attenuate Immune-Mediated Liver Injury in Mice

The Antidepressant Mirtazapine Inhibits Hepatic Innate Immune Networks to Attenuate Immune-Mediated Liver Injury in Mice

Activation of the innate immune system, including tissue macrophages and associated neutrophil infiltration, is an important driver of subsequent adaptive immune responses in many autoimmune diseases, including autoimmune hepatitis (AIH). The antidepressant mirtazapine has a unique complex pharmacol...

Full description

Bibliographic Details
Main Authors: Wagdi Almishri, Abdel Aziz Shaheen, Keith A. Sharkey, Mark G. Swain
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
cytokine
chemokine
autoimmunity
macrophage
neutrophil
flow cytometry
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00803/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00803/full

Similar Items