The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice

The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice

CLEC16A locus polymorphisms have been associated with several autoimmune diseases. We overexpressed CLEC16A in YTS natural killer (NK) cells and observed reduced NK cell cytotoxicity and IFN-γ release, delayed dendritic cell (DC) maturation, decreased conjugate formation, cell-surface receptor downr...

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Bibliographic Details
Main Authors: Rahul Pandey, Marina Bakay, Heather S. Hain, Bryan Strenkowski, Anastasiya Yermakova, Jake A. Kushner, Jordan S. Orange, Hakon Hakonarson
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
CLEC16A
NK cells
cytotoxicity
receptors
cell surface
autophagy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00068/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00068/full

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