Decoding enhancer complexity with machine learning and high-throughput discovery

Abstract Enhancers are genomic DNA elements controlling spatiotemporal gene expression. Their flexible organization and functional redundancies make deciphering their sequence-function relationships challenging. This article provides an overview of the current understanding of enhancer organization...

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Bibliographic Details
Main Authors: Gabrielle D. Smith, Wan Hern Ching, Paola Cornejo-Páramo, Emily S. Wong
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-023-02955-4