Rare variant aggregation in 148,508 exomes identifies genes associated with proxy dementia
Abstract Proxy phenotypes allow for the utilization of genetic data from large population cohorts to analyze late-onset diseases by using parental diagnoses as a proxy for genetic disease risk. Proxy phenotypes based on parental diagnosis status have been used in previous studies to identify common...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-02-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-023-29108-8 |