Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews.
Chronic stress is the major cause of clinical depression. The behavioral signs of depression, including anhedonia, learning and memory deficits, and sleep disruption, result from the damaging effects of stress hormones on specific neural pathways. The Chinese tree shrew (Tupaia belangeri chinensis)...
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| Format: | Article |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24312510/?tool=EBI |
| _version_ | 1818338072384765952 |
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| author | Jing Wang Anping Chai Qixin Zhou Longbao Lv Liping Wang Yuexiong Yang Lin Xu |
| author_facet | Jing Wang Anping Chai Qixin Zhou Longbao Lv Liping Wang Yuexiong Yang Lin Xu |
| author_sort | Jing Wang |
| collection | DOAJ |
| description | Chronic stress is the major cause of clinical depression. The behavioral signs of depression, including anhedonia, learning and memory deficits, and sleep disruption, result from the damaging effects of stress hormones on specific neural pathways. The Chinese tree shrew (Tupaia belangeri chinensis) is an aggressive non-human primate with a hierarchical social structure that has become a well-established model of the behavioral, endocrine, and neurobiological changes associated with stress-induced depression. The tricyclic antidepressant clomipramine treats many of the core symptoms of depression in humans. To further test the validity of the tree shrew model of depression, we examined the effects of clomipramine on depression-like behaviors and physiological stress responses induced by social defeat in subordinate tree shrews. Social defeat led to weight loss, anhedonia (as measured by sucrose preference), unstable fluctuations in locomotor activity, sustained urinary cortisol elevation, irregular cortisol rhythms, and deficient hippocampal long-term potentiation (LTP). Clomipramine ameliorated anhedonia and irregular locomotor activity, and partially rescued the irregular cortisol rhythm. In contrast, weight loss increased, cortisol levels were even higher, and in vitro LTP was still impaired in the clomipramine treatment group. These results demonstrate the unique advantage of the tree shrew social defeat model of depression. |
| first_indexed | 2024-12-13T15:05:18Z |
| format | Article |
| id | doaj.art-ddd27012caf04d8bb46943e8eb77c2a6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T15:05:18Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ddd27012caf04d8bb46943e8eb77c2a62022-12-21T23:41:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8098010.1371/journal.pone.0080980Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews.Jing WangAnping ChaiQixin ZhouLongbao LvLiping WangYuexiong YangLin XuChronic stress is the major cause of clinical depression. The behavioral signs of depression, including anhedonia, learning and memory deficits, and sleep disruption, result from the damaging effects of stress hormones on specific neural pathways. The Chinese tree shrew (Tupaia belangeri chinensis) is an aggressive non-human primate with a hierarchical social structure that has become a well-established model of the behavioral, endocrine, and neurobiological changes associated with stress-induced depression. The tricyclic antidepressant clomipramine treats many of the core symptoms of depression in humans. To further test the validity of the tree shrew model of depression, we examined the effects of clomipramine on depression-like behaviors and physiological stress responses induced by social defeat in subordinate tree shrews. Social defeat led to weight loss, anhedonia (as measured by sucrose preference), unstable fluctuations in locomotor activity, sustained urinary cortisol elevation, irregular cortisol rhythms, and deficient hippocampal long-term potentiation (LTP). Clomipramine ameliorated anhedonia and irregular locomotor activity, and partially rescued the irregular cortisol rhythm. In contrast, weight loss increased, cortisol levels were even higher, and in vitro LTP was still impaired in the clomipramine treatment group. These results demonstrate the unique advantage of the tree shrew social defeat model of depression.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24312510/?tool=EBI |
| spellingShingle | Jing Wang Anping Chai Qixin Zhou Longbao Lv Liping Wang Yuexiong Yang Lin Xu Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews. PLoS ONE |
| title | Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews. |
| title_full | Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews. |
| title_fullStr | Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews. |
| title_full_unstemmed | Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews. |
| title_short | Chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews. |
| title_sort | chronic clomipramine treatment reverses core symptom of depression in subordinate tree shrews |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24312510/?tool=EBI |
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