Inhibition of Nociception in a Preclinical Episodic Migraine Model by Dietary Supplementation of Grape Seed Extract Involves Activation of Endocannabinoid Receptors

Inhibition of Nociception in a Preclinical Episodic Migraine Model by Dietary Supplementation of Grape Seed Extract Involves Activation of Endocannabinoid Receptors

Migraine is associated with peripheral and central sensitization of the trigeminal system and dysfunction of descending pain modulation pathways. Recently, dietary inclusion of grape seed extract (GSE) was shown to inhibit mechanical nociception in a preclinical model of chronic temporomandibular jo...

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Bibliographic Details
Main Authors: Sara E. Woodman, Sophia R. Antonopoulos, Paul L. Durham
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pain Research
Subjects:
cannabinoid receptor
central sensitization
CGRP
migraine
trigeminal
stress
Online Access:https://www.frontiersin.org/articles/10.3389/fpain.2022.809352/full

Internet

https://www.frontiersin.org/articles/10.3389/fpain.2022.809352/full

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