Mitigation of Ionizing Radiation-Induced Gastrointestinal Damage by Insulin-Like Growth Factor-1 in Mice

Mitigation of Ionizing Radiation-Induced Gastrointestinal Damage by Insulin-Like Growth Factor-1 in Mice

Purpose: Insulin-like growth factor-1 (IGF-1) stimulates epithelial regeneration but may also induce life-threatening hypoglycemia. In our study, we first assessed its safety. Subsequently, we examined the effect of IGF-1 administered in different dose regimens on gastrointestinal damage induced by...

Full description

Bibliographic Details
Main Authors: Jaroslav Pejchal, Ales Tichy, Adela Kmochova, Lenka Fikejzlova, Klara Kubelkova, Marcela Milanova, Anna Lierova, Alzbeta Filipova, Lubica Muckova, Jana Cizkova
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
ionizing radiation
mice
insuline-like growth factor- 1
intestine
lung
blood
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.663855/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.663855/full

Similar Items