RNA polymerase II pausing is essential during spermatogenesis for appropriate gene expression and completion of meiosis

RNA polymerase II pausing is essential during spermatogenesis for appropriate gene expression and completion of meiosis

Abstract Male germ cell development requires precise regulation of gene activity in a cell-type and stage-specific manner, with perturbations in gene expression during spermatogenesis associated with infertility. Here, we use steady-state, nascent and single-cell RNA sequencing strategies to compreh...

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Bibliographic Details
Main Authors: Emily G. Kaye, Kavyashree Basavaraju, Geoffrey M. Nelson, Helena D. Zomer, Debarun Roy, Irene Infancy Joseph, Reza Rajabi-Toustani, Huanyu Qiao, Karen Adelman, Prabhakara P. Reddi
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45177-3

Internet

https://doi.org/10.1038/s41467-024-45177-3

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