Porphyrin‐Based SOD Mimic MnTnBuOE‐2‐PyP5+ Inhibits Mechanisms of Aortic Valve Remodeling in Human and Murine Models of Aortic Valve Sclerosis

Porphyrin‐Based SOD Mimic MnTnBuOE‐2‐PyP5+ Inhibits Mechanisms of Aortic Valve Remodeling in Human and Murine Models of Aortic Valve Sclerosis

Background Aortic valve sclerosis (AVSc), the early asymptomatic presentation of calcific aortic valve (AV) disease, affects 25% to 30% of patients aged >65 years. In vitro and ex vivo experiments with antioxidant strategies and antagonists of osteogenic differentiation revealed that AVSc is reve...

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Bibliographic Details
Main Authors: Wanda Anselmo, Emanuela Branchetti, Juan B. Grau, Gen Li, Salma Ayoub, Eric K. Lai, Nancy Rioux, Artak Tovmasyan, Jacqueline H. Fortier, Michael S. Sacks, Ines Batinic‐Haberle, Stanley L. Hazen, Robert J. Levy, Giovanni Ferrari
Format: Article
Language:English
Published: Wiley 2018-10-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
aortic valve stenosis
extracellular matrix
reactive oxygen species
valve
valve interstitial cells
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.117.007861

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https://www.ahajournals.org/doi/10.1161/JAHA.117.007861

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