Sleeve gastrectomy ameliorates renal injury in obesity-combined hyperuricemic nephropathy mice by modulating the AMPK/Nrf2/ABCG2 pathway

Sleeve gastrectomy ameliorates renal injury in obesity-combined hyperuricemic nephropathy mice by modulating the AMPK/Nrf2/ABCG2 pathway

Abstract Hyperuricemic nephropathy (HN) is renal injury caused by hyperuricemia (HUA). While sleeve gastrectomy (SG) has shown promise in improving renal injury in patients with obesity-related HN, the mechanisms are not fully understood. This study induced an obesity-combined HN model in male ob/ob...

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Bibliographic Details
Main Authors: Ke Song, Xiangxin Kong, Zhongyang Zhang, Yin Xian, Ming He, Yuan Zhang, Xinxin Liao, Ziyan Huang, Aijia Kang, Dingqi Xiao, Yixing Ren
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
Sleeve gastrectomy
Hyperuricemic nephropathy
AMPK
Nrf2
ABCG2
Online Access:https://doi.org/10.1038/s41598-024-73807-9

Internet

https://doi.org/10.1038/s41598-024-73807-9

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