Nano-Delivery of a Novel Inhibitor of Polynucleotide Kinase/Phosphatase (PNKP) for Targeted Sensitization of Colorectal Cancer to Radiation-Induced DNA Damage

Nano-Delivery of a Novel Inhibitor of Polynucleotide Kinase/Phosphatase (PNKP) for Targeted Sensitization of Colorectal Cancer to Radiation-Induced DNA Damage

Inhibition of the DNA repair enzyme polynucleotide kinase/phosphatase (PNKP) increases the sensitivity of cancer cells to DNA damage by ionizing radiation (IR). We have developed a novel inhibitor of PNKP, i.e., A83B4C63, as a potential radio-sensitizer for the treatment of solid tumors. Systemic de...

Full description

Bibliographic Details
Main Authors: Sams M. A. Sadat, Melinda Wuest, Igor M. Paiva, Sirazum Munira, Nasim Sarrami, Forughalsadat Sanaee, Xiaoyan Yang, Marco Paladino, Ziyad Binkhathlan, Feridoun Karimi-Busheri, Gary R. Martin, Frank R. Jirik, David Murray, Armin M. Gamper, Dennis G. Hall, Michael Weinfeld, Afsaneh Lavasanifar
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Oncology
Subjects:
DNA repair
DNA damage
PNKP
radio-sensitization
colorectal cancer
ionizing radiation
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.772920/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.772920/full

Similar Items