Genetics implicates overactive osteogenesis in the development of diffuse idiopathic skeletal hyperostosis

Abstract Diffuse idiopathic skeletal hyperostosis (DISH) is a condition where adjacent vertebrae become fused through formation of osteophytes. The genetic and epidemiological etiology of this condition is not well understood. Here, we implemented a machine learning algorithm to assess the prevalenc...

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Bibliographic Details
Main Authors: Anurag Sethi, J. Graham Ruby, Matthew A. Veras, Natalie Telis, Eugene Melamud
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38279-x