Substantial histone reduction modulates genomewide nucleosomal occupancy and global transcriptional output.

Substantial histone reduction modulates genomewide nucleosomal occupancy and global transcriptional output.

The basic unit of genome packaging is the nucleosome, and nucleosomes have long been proposed to restrict DNA accessibility both to damage and to transcription. Nucleosome number in cells was considered fixed, but recently aging yeast and mammalian cells were shown to contain fewer nucleosomes. We s...

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Bibliographic Details
Main Authors: Barbara Celona, Assaf Weiner, Francesca Di Felice, Francesco M Mancuso, Elisa Cesarini, Riccardo L Rossi, Lorna Gregory, Dilair Baban, Grazisa Rossetti, Paolo Grianti, Massimiliano Pagani, Tiziana Bonaldi, Jiannis Ragoussis, Nir Friedman, Giorgio Camilloni, Marco E Bianchi, Alessandra Agresti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-06-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21738444/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21738444/?tool=EBI

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