Unexpected Salt/Cocrystal Polymorphism of the Ketoprofen–Lysine System: Discovery of a New Ketoprofen–<span style="font-variant: small-caps">l</span>-Lysine Salt Polymorph with Different Physicochemical and Pharmacokinetic Properties

Unexpected Salt/Cocrystal Polymorphism of the Ketoprofen–Lysine System: Discovery of a New Ketoprofen–<span style="font-variant: small-caps">l</span>-Lysine Salt Polymorph with Different Physicochemical and Pharmacokinetic Properties

Ketoprofen–<span style="font-variant: small-caps;">l</span>-lysine salt (KLS) is a widely used nonsteroidal anti-inflammatory drug. Here, we studied deeply the solid-state characteristics of KLS to possibly identify new polymorphic drugs. Conducting a polymorph screening study...

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Bibliographic Details
Main Authors: Andrea Aramini, Gianluca Bianchini, Samuele Lillini, Simone Bordignon, Mara Tomassetti, Rubina Novelli, Simone Mattioli, Larisa Lvova, Roberto Paolesse, Michele Remo Chierotti, Marcello Allegretti
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceuticals
Subjects:
ketoprofen–<span style="font-variant: small-caps">l</span>-lysine salt
cocrystal
salt
polymorphism
faster-release formulation
Online Access:https://www.mdpi.com/1424-8247/14/6/555

Internet

https://www.mdpi.com/1424-8247/14/6/555

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