Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ

Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ

Professional antigen presenting cells (APC) are the major activator of T cells that then hone to sites of inflammation. Using islet cell grafts, here the authors show that parenchymal cells can present antigen to activate CD8+T cells at inflammatory sites, coining this a ‘mezzanine response’ distinc...

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Bibliographic Details
Main Authors: Robyn M. Sutherland, Sarah L. Londrigan, Jamie L. Brady, Emma M. Carrington, Julia M. Marchingo, Susanne Heinzel, Philip D. Hodgkin, Kate L. Graham, Thomas W. Kay, Yifan Zhan, Andrew M. Lew
Format: Article
Language:English
Published: Nature Portfolio 2017-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14809

Internet

https://doi.org/10.1038/ncomms14809

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