Supplementation with N-3 long-chain polyunsaturated fatty acids or olive oil in men and women with renal disease induces differential changes in the DNA methylation of FADS2 and ELOVL5 in peripheral blood mononuclear cells.

Supplementation with N-3 long-chain polyunsaturated fatty acids or olive oil in men and women with renal disease induces differential changes in the DNA methylation of FADS2 and ELOVL5 in peripheral blood mononuclear cells.

BACKGROUND: Studies in animal models and in cultured cells have shown that fatty acids can induce alterations in the DNA methylation of specific genes. There have been no studies of the effects of fatty acid supplementation on the epigenetic regulation of genes in adult humans. METHODS AND RESULTS:...

Full description

Bibliographic Details
Main Authors: Samuel P Hoile, Rebecca Clarke-Harris, Rae-Chi Huang, Philip C Calder, Trevor A Mori, Lawrence J Beilin, Karen A Lillycrop, Graham C Burdge
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4201459?pdf=render

Internet

http://europepmc.org/articles/PMC4201459?pdf=render

Similar Items