Efficient and scalable clarification of Orf virus from HEK suspension for vaccine development

Efficient and scalable clarification of Orf virus from HEK suspension for vaccine development

The Orf virus (ORFV) is a promising vector platform for the generation of vaccines against infectious diseases and cancer, highlighted by its progression to clinical testing phases. One of the critical steps during GMP manufacturing is the clarification of crude harvest because of the enveloped natu...

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Bibliographic Details
Main Authors: Felix Pagallies, Jennifer J. Labisch, Malgorzata Wronska, Karl Pflanz, Ralf Amann
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Vaccine: X
Subjects:
Harvest
Clarification
Parapoxvirus Orf
Nuclease treatment
Multi-parallel filtration
Filter screening
Online Access:http://www.sciencedirect.com/science/article/pii/S2590136224000470

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http://www.sciencedirect.com/science/article/pii/S2590136224000470

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