Adjuvant effect of enterotoxigenic Escherichia coli (ETEC) double-mutant heat-labile toxin (dmLT) on systemic immunogenicity induced by the CFA/I/II/IV MEFA ETEC vaccine: Dose-related enhancement of antibody responses to seven ETEC adhesins (CFA/I, CS1-CS6)

Adjuvant effect of enterotoxigenic Escherichia coli (ETEC) double-mutant heat-labile toxin (dmLT) on systemic immunogenicity induced by the CFA/I/II/IV MEFA ETEC vaccine: Dose-related enhancement of antibody responses to seven ETEC adhesins (CFA/I, CS1-CS6)

Double-mutant heat-labile toxin (dmLT, LTR192G/L211A) of enterotoxigenic Escherichia coli (ETEC) is an effective mucosal adjuvant. Recent studies have shown that dmLT also exhibits adjuvanticity for antigens administered parenterally. In this study, we subcutaneously (SC) immunized mice with the ETE...

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Bibliographic Details
Main Authors: Hyesuk Seo, Ti Lu, Sachin Mani, A. Louis Bourgeois, Richard Walker, David A. Sack, Weiping Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2020-02-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
dmlt
adjuvant
dose effect
cfa/i/ii/iv mefa
enterotoxigenic escherichia coli (etec)
antibody response
Online Access:http://dx.doi.org/10.1080/21645515.2019.1649555

Internet

http://dx.doi.org/10.1080/21645515.2019.1649555

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