Purification and In Vitro Evaluation of an Anti-HER2 Affibody-Monomethyl Auristatin E Conjugate in HER2-Positive Cancer Cells

Purification and In Vitro Evaluation of an Anti-HER2 Affibody-Monomethyl Auristatin E Conjugate in HER2-Positive Cancer Cells

A promising approach for the development of high-affinity tumor targeting ADCs is the use of engineered protein drugs, such as affibody molecules, which represent a valuable alternative to monoclonal antibodies (mAbs) in cancer-targeted therapy. We developed a method for a more efficient purificatio...

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Bibliographic Details
Main Authors: Isabella Damiani, Silvia Castiglioni, Alicja Sochaj-Gregorczyk, Fabrizia Bonacina, Irma Colombo, Valentina Rusconi, Jacek Otlewski, Alberto Corsini, Stefano Bellosta
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biology
Subjects:
affibody
breast cancer
HER2 overexpression
target therapy
Online Access:https://www.mdpi.com/2079-7737/10/8/758

Internet

https://www.mdpi.com/2079-7737/10/8/758

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