Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3

Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3

Abstract Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present cryo-electron microscopy structures of two human CC chemokine receptor–G-protein complexes: CCR2 bound to its endogenous ligand CCL2, and CCR3 i...

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Bibliographic Details
Main Authors: Zhehua Shao, Yangxia Tan, Qingya Shen, Li Hou, Bingpeng Yao, Jiao Qin, Peiyu Xu, Chunyou Mao, Li-Nan Chen, Huibing Zhang, Dan-Dan Shen, Chao Zhang, Weijie Li, Xufei Du, Fei Li, Zhi-Hua Chen, Yi Jiang, H. Eric Xu, Songmin Ying, Honglei Ma, Yan Zhang, Huahao Shen
Format: Article
Language:English
Published: Nature Publishing Group 2022-05-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-022-00403-4

Internet

https://doi.org/10.1038/s41421-022-00403-4

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