RNA-mediated ribonucleoprotein assembly controls TDP-43 nuclear retention.

RNA-mediated ribonucleoprotein assembly controls TDP-43 nuclear retention.

TDP-43 is an essential RNA-binding protein strongly implicated in the pathogenesis of neurodegenerative disorders characterized by cytoplasmic aggregates and loss of nuclear TDP-43. The protein shuttles between nucleus and cytoplasm, yet maintaining predominantly nuclear TDP-43 localization is impor...

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Bibliographic Details
Main Authors: Patricia M Dos Passos, Erandika H Hemamali, Lohany D Mamede, Lindsey R Hayes, Yuna M Ayala
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-02-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002527&type=printable

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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002527&type=printable

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