Detection of inferred CCR5- and CXCR4-using HIV-1 variants and evolutionary intermediates using ultra-deep pyrosequencing.

Detection of inferred CCR5- and CXCR4-using HIV-1 variants and evolutionary intermediates using ultra-deep pyrosequencing.

The emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants is associated with accelerated disease progression. CXCR4-using variants are believed to evolve from CCR5-using variants, but due to the extremely low frequency at which transitional intermediate variants are often pre...

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Bibliographic Details
Main Authors: Evelien M Bunnik, Luke C Swenson, Diana Edo-Matas, Wei Huang, Winnie Dong, Arne Frantzell, Christos J Petropoulos, Eoin Coakley, Hanneke Schuitemaker, P Richard Harrigan, Angélique B van 't Wout
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-06-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3121885?pdf=render

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http://europepmc.org/articles/PMC3121885?pdf=render

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