Vaccinia virus induces rapid necrosis in keratinocytes by a STAT3-dependent mechanism.

Vaccinia virus induces rapid necrosis in keratinocytes by a STAT3-dependent mechanism.

Humans with a dominant negative mutation in STAT3 are susceptible to severe skin infections, suggesting an essential role for STAT3 signaling in defense against cutaneous pathogens.To focus on innate antiviral defenses in keratinocytes, we used a standard model of cutaneous infection of severe combi...

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Bibliographic Details
Main Authors: Yong He, Robert Fisher, Soma Chowdhury, Ishrat Sultana, Claudia P Pereira, Mike Bray, Jennifer L Reed
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4242661?pdf=render

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http://europepmc.org/articles/PMC4242661?pdf=render

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