Amyloid-Beta Peptides Trigger Premature Functional and Gene Expression Alterations in Human-Induced Neurons

Amyloid-Beta Peptides Trigger Premature Functional and Gene Expression Alterations in Human-Induced Neurons

Alzheimer’s disease (AD) is the most prevalent cause of dementia in the elderly, characterized by the presence of amyloid-beta (Aβ) plaques, neurofibrillary tangles, neuroinflammation, synapse loss and neurodegeneration in the brain. The amyloid cascade hypothesis postulates that deposition of Aβ pe...

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Bibliographic Details
Main Authors: Ana Raquel Melo de Farias, Alexandre Pelletier, Lukas Cruz Carvalho Iohan, Orthis Saha, Amélie Bonnefond, Philippe Amouyel, Fabien Delahaye, Jean-Charles Lambert, Marcos R. Costa
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Biomedicines
Subjects:
amyloid-beta peptides
human-induced neurons
single-nucleus RNA sequencing
calcium imaging
inter-cellular communication
Online Access:https://www.mdpi.com/2227-9059/11/9/2564

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https://www.mdpi.com/2227-9059/11/9/2564

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