Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis

Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis

Abstract Cerebrospinal fluid (CSF) biomarkers play an important role in diagnosing Alzheimer’s disease (AD) which is characterized by amyloid-β (Aβ) amyloidosis. Here, we used two App knock-in mouse models, App NL-F/NL-F and App NL-G-F/NL-G-F , exhibiting AD-like Aβ pathology to analyze how the brai...

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Bibliographic Details
Main Authors: Richeng Jiang, Una Smailovic, Hazal Haytural, Betty M. Tijms, Hao Li, Robert Mihai Haret, Ganna Shevchenko, Gefei Chen, Axel Abelein, Johan Gobom, Susanne Frykman, Misaki Sekiguchi, Ryo Fujioka, Naoto Watamura, Hiroki Sasaguri, Sofie Nyström, Per Hammarström, Takaomi C. Saido, Vesna Jelic, Stina Syvänen, Henrik Zetterberg, Bengt Winblad, Jonas Bergquist, Pieter Jelle Visser, Per Nilsson
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Decorin
Cerebrospinal fluid
Mass spectrometry
App knock-in mice
Amyloid-β (Aβ)
Online Access:https://doi.org/10.1186/s40478-022-01398-5

Internet

https://doi.org/10.1186/s40478-022-01398-5

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